Study was basically assessed by about three-means ANOVA that have pairwise analysis followed closely by Tukey’s blog post hoc attempt

Associations

The primary goal of this study was to analyze urinary Na + , K + and the Na + :K + excretion ratio, for associations with changes in systolic blood pressure (SBP) in participants from the DASH–Sodium trial during the initial screening period in which participants were consuming their regular diet without dietary intervention. The secondary goals of this study were to investigate: (a) the impact of the salt sensitivity of blood pressure on these responses and (b) the impact of the DASH–Sodium dietary intervention, which lowers SBP and increases dietary K + intake, on these potential associations. Our analysis reports that in the DASH–Sodium study cohort: (1) a daily excretion of <1 g K + /day is associated with elevated SBP, (2) urinary K + excretion of >1 g/day does not correlate with a reduction in SBP and, (3) a reduction in the urinary Na + :K + excretion ratio is not associated with lower SBP irrespective of the salt sensitivity of blood pressure. Collectively our data support the recent DRI recommendation not to propose a DRI for K + and suggest that further evidence is required to support the establishment of a Na + /K + excretion ratio that would reduce SBP in the general population.

Logical details

Mean SBP relative to urinary salt so you’re able to potassium (Na + /K + ) removal ratio in the course of examination and with losing weight intervention out of Weight loss Solutions to Avoid Blood pressure levels (DASH) large sodium (HS) and you will lower sodium (LS) diet plan for the (a) sodium delicate (n = 71), (b) salt resistant (letter = 119) some body, values found as suggest ± SD.

Significantly, we observed no association between the urinary Na + :K + ratio and SBP on the DASH HS or DASH LS dietary intervention in either SS (DASH HS R 2 = 0.04, DASH LS R 2 = 0.02) or SR (DASH HS R 2 = 0.04, DASH LS R 2 = 0.00002) participants (Fig. 5a, b). The DASH dietary intervention significantly increased the number of participants in both SS and SR groups with a urinary Na + :K + ratio of <1 on both the HS and LS diet. However, the urinary Na + :K + had no impact on SBP within dietary intake groups (Fig. 6a, b). Further, when expressed as a frequency distribution histogram the change in SBP from the DASH HS to LS dietary intervention exhibits a profound leftward shift in the SS group compared to SR group (Fig. 7a). In contrast, the frequency distribution histogram for change in the urinary Na + :K + ratio from the DASH HS to LS dietary intervention shows no difference in the Gaussian curve and distribution between SS and SR participants (Fig. 7b).

Next, multiple research has advised that the blood pressure reduction evoked because of the K + consumption is generally determined by dieting Na + intake [twenty eight, 29]. Within our study of your Dash-Salt dataset i noticed zero relationship with urinary K + removal and jdate you will SBP, inside patient tests visit or while in the Dashboard fat reduction intervention whenever Na + intake was changed, recommending a versatility of one’s aftereffects of Na + and you can K + to your SBP in this studies. Brand new 2019 DRI Statement concluded that there was shortage of facts to your the effects away from K + to the blood circulation pressure and you can failed to establish a good DRI regarding K + . The investigation keep the 2019 DRI Report and you may implies that slimming down K + supplementation might not somewhat reduce blood pressure levels on the standard society.

Summary

Stamler J, Rose Grams, Stamler R, Elliott P, Dyer A good, Marmot Meters. INTERSALT investigation results. Personal health and healthcare effects. Blood pressure levels. 1989;–seven.